If you look at my blog, you will find my message regarding side effects
of beta stimulants and magnesium sulfate.
Having read that, I am sure you will believe about harmful effects of these
drugs on the fetus.

 During my clinical practices in the past, I have never used beta stimulants
or magnesium sulfate.

 I used estrogen-progestin dose escalating therapy for treating pregnancy
induced hypertension, and mainly progestin therapy for treating
preterm labor, or estrogen-progestin dose escalating regimen for
severe cases of preterm labor. By using these therapies, I could
successfully avoid using beta stimulants and magnesium sulfate.

 My blog: NPO caring mothers and fetus of pregnancy induced hypertension
and preterm labor. The first NPO general meeting was held in 2011,
where my patient of severe pregnancy induced hypertension treated with
my hormonal therapy in 1975 at Shizuoka Saiseikai hospital,
together with her daughter (currently a mother of two children) joined
our meeting. The safety of my hormonal therapy is thus proved in
two generations. (refer to NPO home page )

On February 4th 2011, Food and Drug Administration
(FDA; equivalent to Japanese Ministry of Health and Welfare) approved
a natural progesterone preparation (Makena) indicated for preventing
 threatened preterm labor. The approval was on the fast truck
approval procedure so that the drug can be used in the market
as soon as possible.

20 days after the approval of Makena, FDA announced the restriction
of the use of terbutaline (beta stimulant) over 72 hours. FDA
’s quick
reactions for switching drugs to a safer one and ban a harmful drug is
determining attitude.

Currently, natural progestin preparation (ohhormin depot) has been
approved in Japan for threatened preterm labor since long time before,
and can be used at present.

A certain vaginal hormonal preparation seemed to be on the clinical trial
in Japan, however, it seemed that the FDA did not approve progestin
vaginal preparation for the use of threatened preterm labor in the US.

Not knowing the reasons of FDA’s decision, but I would like to emphasize
again that, the natural progesterone (Makena; 17 alpha progesterone
caproate) is available in Japan at present. Instead of using harmful drugs
such as beta stimulants or magnesium sulfate, why not using
estrogen-progesterone dose escalating method, which I have been using
since 1970s. I do not understand why the Japanese obstetricians do not
try to use this safe and effective therapy.


 


Reference:

Sex steroid therapy for pregnancy induced hypertension. Journal for Japan Neonatology Society.
1978; 14:534-560

 

Mizutani S et al. Positive effect of estradiol and progesterone in severe preeclampsia . Exp. Clin.
 Endocrinol.1988;92:161-170

 

Naruki M, Mizutani S et al. Changes in maternal serum oxytocinase activities in preterm labour.
Med. Sci. Res. 1995;23:797-802