その年、1970年の冬、スミス博士の治療法:前回のブログ:ホルモン療法との出会い(2)を重症妊娠中毒症患者さんに試す機会が訪れました。
ところが、この治療法を試すまでには、思わぬ障害が待っていました。当時、日本の周産期医療ではエストロゲンとプロゲステロンを妊婦に使うのは一般的ではありませんでした。エストロゲンは現在も禁忌とされています。
そこで、妊婦の同意を取り付けて、父が経営していた産婦人科医院の患者として治療することにしました。
その年、1970年の冬、スミス博士の治療法:前回のブログ:ホルモン療法との出会い(2)を重症妊娠中毒症患者さんに試す機会が訪れました。
ところが、この治療法を試すまでには、思わぬ障害が待っていました。当時、日本の周産期医療ではエストロゲンとプロゲステロンを妊婦に使うのは一般的ではありませんでした。エストロゲンは現在も禁忌とされています。
そこで、妊婦の同意を取り付けて、父が経営していた産婦人科医院の患者として治療することにしました。
In 1970 winter, I had a chance to try sex steroid hormone therapy
for severe preeclampsia, the therapy which was proposed by
Drs. Smith (my previous blog). However my attempt of this plan
was not acknowledged in the treatment of preeclampsia in
at that time. In
hormones for pregnant women at that time. Estradiol administration
for pregnant women is not yet acknowledged except for in vitro
fertilization. Therefore at my hospital (
I could not execute my plan. My father then had his small private
hospital in
hospital. With the consent of this trial for severe preeclampsia patient
and her husband I could start this treatment in the end of December 1970.
Dr. Smith administered estradiol and progesterone at the fixed dose and
continued throughout the treatment. However I altered the doses of both
hormones in accordance with advancing gestation (Home page of our NPO,
Natural hormonal therapy for pregnancy induced hypertension and
preterm birth) During IVF treatment not only obstetricians but also patients
could know that blood levels of both hormones (estradiol and progesterone)
are very important in the prognosis of implantation (pregnancy). Since these
hormone levels in blood are definitive for implantation of
fertilized egg(pregnancy), it is also important as they are essential for
continuation of normal pregnancy.
Encounter with sex steroid hormone therapy in severe preeclampsia (No2):
Blood Sex steroid hormone (estradiol and progesterone) levels in pregnant
women are enormously increased at late stage of pregnancy compared with
those in non-pregnant women.
Female sex hormone is estradiol and progesterone. Estrogen is secreted
from ovary and its level in blood is increased at maximum just before
ovulation in women suggesting that this hormone is essential for ovum
maturation. Progesterone is secreted just after ovulation and its level in
blood is increased at maximum around 7 day after ovulation suggesting
that this hormone is essential for implantation of ovum: beginning and
continuation of pregnancy. Among estrogen hormones estradiol is the
most bioactive hormone.
エストロゲン(卵胞ホルモン)とプロゲステロン(黄体ホルモン):女性ホルモンとは、この2つのことです。
・・・続きは会員限定です。
また、理事長の著書「妊娠中毒症と早産の最新ホルモン治療」には、今回の記事の内容が詳しく書いてあります。ぜひ一度ご覧下さい。
アマゾンからお買い求めいただけます。
Also some day in summer of 1970 I have been at a loss regarding to how
to treat severe preeclampsia patients. I happened to be focused on some
sentence of Japanese book on steroid hormones. The sentence mentioned
that injection of sex steroid (estradiol plus progesterone ) was effective in
alleviation of severe preeclampsia before world war Ⅱin USA.
Since I was fascinated with this evidence, I have searched the original
manuscript on this interesting mentioning. It was difficult to find this
manuscript. However I could find this article at the library of Tokyo University.
The article is as follows: since the levels of both steroids in urine with severe
preeclampsia patients, Dr. Smith and Smith in Boston Lying in Hospital treated
using both steroids by intramuscular injection with severe preeclampsia patients
and they found their treatment was effective in alleviation of severe
preeclampsia(1). At that time it was known that urinary estrogen and
progesterone levels with severe preeclampsia patients was much lower than
normal pregnant women.
The theory by Dr. Smith and Smith on their treatment was very simple: