In 1975 winter I had a chance to try sex steroid treatment on severe preeclampsia. I was working at hospital in Shizuoka City at that time. The patient was 29 years old and had a history of severe preeclampsia in previous pregnancy. She was hospitalized at week 29 because of hypertension (150/84 mmHg), proteinuria and slight edema. On the 7th day with bed rest, however, the blood pressure rose further to 164/100 mmHg, and proteinuria increased, so treatment with sex steroids was started and maintained for 24 days. After administration of sex steroids her P-LAP value continued to rise progressively up to 74.0 unit at week 32. Along with this treatment there was a gradual fall of blood pressure and an improvement of edema. Since then the P-LAP level showed a decreasing tendency for 9 days and the blood pressure had risen despite the sex steroids treatment. Consequently, at week 34 a female infant weighing 1,850g (Apgar score 9) was delivered by Cesarean section.

Before sex steroid treatment at my clinic visit I explained to this patient that according to the conventional treatment such as antihypertensive agents and diuretics she may not get well. I proposed sex steroid treatment to this patient, which is completely different from the conventional treatment and explained about it precisely. After that she relied on me to treat her with sex steroids.

Later I have noticed that my colleague doctors said to her that she may die due to sex steroid treatment.

When I have intended to organize our NPO in last year, I have phoned to this patient (now she is 67 years old) and hoped her to attending to our NPO. Fortunately she and her female infant (now 38 years old and she has 2 healthy children) are active members of our NPO.

 According to my experience with the treatment by sex steroids on two cases of severe preeclampsia, I could convince myself that sex steroid treatment is effective for alleviation on severe preeclampsia. However it is important to know that the sex steroid treatment has the limitation of its continued efficacy within 3 gestational weeks for treatment of severe preeclampsia. In addition, both serial measurements of P-LAP in pregnancy serum and strict observation with clinical symptoms such as blood pressure are essential for judging its limitation.

During my long experience as a clinician, including the time working as the chairman of the department of OB/GY, Nagoya University School of Medicine, it was hard for me that the significance of sex steroid treatment for severe preeclampsia is to be approved by my colleagues. Therefore there are a few severe preeclampsia patients who were treated by sex steroids.

I have treated both severe preeclampsia and preterm labor by sex steroids amounting around 20 cases until now. I would appreciate it if you would kindly check top page of our NPO (http: //www. p-lap.org/) concerning with natural hormonal therapy.